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This volume includes papers from the National Academy of Engineering's 1998 US Frontiers of Engineering (USFOE) Symposium held in September 1998. USFOE meetings bring together 100 outstanding engineers (ages 30 to 45) to exchange information about leading-edge technologies in a range of engineering fields. The 1998 symposium covered four topic areas: Biomaterials and optical imaging for biomedicine, Advanced materials, Simulation in manufacturing, and Robotics. Appendixes include information about contributors, the symposium program, and a list of meeting participants.